研究紹介

Analyzing Brain Structural Changes for Insights on Psychiatric Disease Mechanisms

  • 大規模な脳画像研究の推進によって統合失調症などの精神疾患の理解が進みました。今後、大規模脳画像データベースから得られた成果をもとに、病態解明や臨床応用に向けた研究が進むことが期待されます。
  • 1)
    Okada et al.
    Abnormal asymmetries in subcortical brain volume in schizophrenia
    Molecular Psychiatry 2016
    doi: 10.1038/mp.2015.209.
    2)
    Okada et al.
    Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences
    Translational Psychiatry 2018
    doi: 10.1038/s41398-018-0312-6
    3)
    Sasabayashi et al.
    Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State
    Schizophrenia Bulletin 2020
    doi: 10.1093/schbul/sbaa011
    4)
    Zhu et al.
    Application of a Machine Learning Algorithm for Structural Brain Images in Chronic Schizophrenia to Earlier Clinical Stages of Psychosis and Autism Spectrum Disorder: A Multiprotocol Imaging Dataset Study
    Schizophrenia Bulletin 2022
    doi: 10.1093/schbul/sbac030

Mismatch Negativity: A Crucial Marker for Early Detection of Schizophrenia

  • ミスマッチ陰性電位(Mismatch Negativity)は人だけでなく動物でも測定できるトランスレータブルなバイオマーカーです。このような特徴を活かし、統合失調症などの精神疾患の病態解明に役立つことが期待されます。
  • 1)
    Koshiyama D et al.
    Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
    Schizophrenia Research 2018
    doi: 10.1016/j.schres.2017.09.045.
    2)
    Koshiyama D et al.
    Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia
    Schizophria Bulletin 2020
    doi: 10.1093/schbul/sbaa006.
    3)
    Ishishita Y et al.
    Deviance detection is the dominant component of auditory contextual processing in the lateral superior temporal gyrus: A human ECoG study
    Human Brain Mapping 2019
    doi: 10.1002/hbm.24438.
    4)
    Suda Y et al.
    Prediction-Related Frontal-Temporal Network for Omission Mismatch Activity in the Macaque Monkey
    Frontiers in Psychiatry 2022
    doi: 10.3389/fpsyt.2022.557954.
    5)
    Tada M et al.
    Translatability of Scalp EEG Recordings of Duration-Deviant Mismatch Negativity Between Macaques and Humans: A Pilot Study
    Frontiers in Psychiatry 2020
    doi: 10.3389/fpsyt.2020.00874.